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Anti-TNF Antibody

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human TNF Antibody MOM-18062 1mg Please Inquiry
Product Detail
Cat
MOM-18062
Product Overview
Recombinant Human Antibody is bind to Human TNF alpha, expressed in Chinese Hamster Ovary cells(CHO)
Target
TNF alpha
Type
Human IgG1 - kappa
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, IHC and most other immunological methods.
Specificity
Tested positive against native antigen.
Protein Construction
Immunoglobulin G1, anti (human tumor necrosis factor) (human monoclonal CNTO148 heavy chain), disulfide with human monoclonal CNTO148 light chain), dimer
Predicted N terminal
H Chain: QVQLVES; L Chain: EIVLTQS
Purity
>95.0% as determined by analysis by RP-HPLC.
Storage
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Background
Antigen Description
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
Function
cytokine activity; identical protein binding; protease binding; protein binding; transcription regulatory region DNA binding; tumor necrosis factor receptor binding;
Gene ID
7124
Keywords
0
Synonyms
TNF; tumor necrosis factor; TNFA, tumor necrosis factor (TNF superfamily, member 2); DIF; TNF superfamily; member 2; TNF alpha; TNFSF2; TNF-a; cachectin; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; TNF superfamily, member 2; tumor necrosis factor alpha; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2; TNFA; TNF-alpha;
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