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Anti-TNFRSF10B Antibody

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human TNFRSF10B Antibody MOM-18196 1mg Please Inquiry
Product Detail
Cat
MOM-18196
Product Overview
Recombinant Humanized (from mouse) Antibody is against Human TRAIL-R2, expressed in Chinese Hamster Ovary cells(CHO)
Target
TRAIL-R2
Type
Humanized (from mouse) IgG1
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
Specificity
Tested positive against native antigen.
Protein Construction
Immunoglobulin G1, anti-[Homo sapiens TNFRSF10B (tumor necrosis factor receptor superfamily member 10b, DR5, TRAIL-R2, CD262)] humanized monoclonal TRA-8 (or CS-1008); gamma1 heavy chain [humanized VH (Homo sapiens FR/Mus musculus CDR)[8.8.12] -Homo sapie
Predicted N terminal
H chain: EVQLVES; L Chain: DIQMTQS
Purity
>95%, by SDS-PAGE with silver staining, under reducing conditions.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Background
Antigen Description
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
Function
TRAIL binding; protein binding; receptor activity;
Gene ID
8795
Synonyms
TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor superfamily member 10B; CD262; DR5; KILLER; TRAIL R2; TRICK2A; TRICKB; Fas-like protein; death receptor 5; cytotoxic TRAIL receptor-2; apoptosis inducing receptor TRAIL-R2; apoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-inducing ligand receptor 2; death domain containing receptor for TRAIL/Apo-2L; tumor necrosis factor receptor-like protein ZTNFR9; p53-regulated DNA damage-inducible cell death receptor(killer); TRICK2; ZTNFR9; TRAILR2; TRICK2B; TRAIL-R2; KILLER/DR5;
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