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Anti-dkk1 Antibody Fab

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human dkk1 Antibody Fab Fragment MOM-18550-F(E) 1mg Please Inquiry
Product Detail
Cat
MOM-18550-F(E)
Product Overview
Recombinant Mouse Antibody Fab Fragment specifically binds to Human DKK1, expressed in Chinese Hamster Ovary cells(CHO)
Target
DKK1
Type
Fab
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Specificity
Tested positive against native antigen.
Purity
>95.0% as determined by analysis by SDS-PAGE.
Storage
Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Background
Antigen Description
Antaggedonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Function
growth factor activity; low-density lipoprotein particle receptor binding; protein binding; receptor antaggedonist activity; signal transducer activity;
Gene ID
22943
Synonyms
DKK1; dickkopf 1 homolog (Xenopus laevis); dickkopf (Xenopus laevis) homolog 1; dickkopf-related protein 1; DKK 1; SK; hDkk-1; dickkopf-1 like; dickkopf related protein-1; DKK-1;
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