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Anti-il21r Antibody scFv

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human il21r Antibody scFv Fragment MOM-18394-S(P) 1mg Please Inquiry
Product Detail
Cat
MOM-18394-S(P)
Product Overview
Recombinant Mouse Antibody scFv Fragment specifically binds to Human IL21R, expressed in E. coli
Target
IL21R
Type
scFv
Immunogen
Rat YB2/0 hybridoma transfectant cell line expressing truncated Mouse IL21 Receptor
Species Reactivity
Human
Expression Host
E. coli
Applications
Suitable for use in ELISA, WB, Neut and most other immunological methods.
Specificity
Tested positive against native antigen.
Purity
>95.0% as determined by analysis by SDS-PAGE.
Storage
Store at -20°C. Avoid multiple freeze/thaw cycles.
Background
Antigen Description
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.
Function
interleukin-21 receptor activity; receptor activity;
Gene ID
50615
Synonyms
IL21R; interleukin 21 receptor; interleukin-21 receptor; CD360; IL-21R; IL-21 receptor; novel interleukin receptor; NILR; MGC10967
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