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Anti-nfkbib Antibody Fab

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human nfkbib Antibody Fab Fragment MOM-18444-F(P) 1mg Please Inquiry
Product Detail
Cat
MOM-18444-F(P)
Product Overview
Recombinant Mouse Antibody Fab Fragment binds selectively to Human NFKBIB, expressed in E. coli
Target
NFKBIB
Type
Fab
Immunogen
Purified recombinant fragment of Human IKB beta expressed in E. Coli.
Species Reactivity
Human
Expression Host
E. coli
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Specificity
Tested positive against native antigen.
Purity
>95.0% as determined by analysis by RP-HPLC.
Storage
Store at -20°C. Avoid multiple freeze/thaw cycles.
Background
Antigen Description
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Function
protein binding; signal transducer activity; transcription coactivator activity;
Gene ID
4793
Synonyms
NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta; NF-kappa-B inhibitor beta; IKBB; TRIP9; ikB-B; TRIP-9; ikB-beta; ikappaBbeta; NF-kappa-BIB; I-kappa-B-beta; TR-interacting protein 9; thyroid receptor-interacting protein 9
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