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Anti-psen1 Antibody Fab

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human psen1 Antibody Fab Fragment MOM-18475-F(P) 1mg Please Inquiry
Product Detail
Cat
MOM-18475-F(P)
Product Overview
Recombinant Mouse Antibody Fab Fragment is against Human PSEN1, expressed in E. coli
Target
PSEN1
Type
Fab
Immunogen
Synthetic peptide: HLSNTVRSQNDNRE, corresponding to amino acids 21-34 of Human Presenilin 1 with N-terminally added cysteine.HLSNTVRSQNDNRE
Species Reactivity
Human
Expression Host
E. coli
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Specificity
Tested positive against native antigen.
Purity
>95.0% as determined by analysis by RP-HPLC.
Storage
Store at -20°C. Avoid multiple freeze/thaw cycles.
Background
Antigen Description
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
Function
PDZ domain binding; aspartic-type endopeptidase activity; beta-catenin binding; cadherin binding; calcium channel activity; endopeptidase activity; endopeptidase activity; peptidase activity; protein binding;
Gene ID
5663
Synonyms
PSEN1; presenilin 1; AD3, Alzheimer disease 3; presenilin-1; FAD; PS1; S182; AD3; PS-1
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