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Anti-psen1 Antibody

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human psen1 Antibody MOM-18475 1mg Please Inquiry
Product Detail
Cat
MOM-18475
Product Overview
Recombinant Mouse Antibody is specific to Human PSEN1, expressed in Chinese Hamster Ovary cells(CHO)
Target
PSEN1
Type
IgG
Immunogen
Synthetic peptide: HLSNTVRSQNDNRE, corresponding to amino acids 21-34 of Human Presenilin 1 with N-terminally added cysteine.HLSNTVRSQNDNRE
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in Neut, FuncS, IF and most other immunological methods.
Specificity
Tested positive against native antigen.
Purity
>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Storage
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Background
Antigen Description
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
Function
PDZ domain binding; aspartic-type endopeptidase activity; beta-catenin binding; cadherin binding; calcium channel activity; endopeptidase activity; endopeptidase activity; peptidase activity; protein binding;
Gene ID
5663
Synonyms
PSEN1; presenilin 1; AD3, Alzheimer disease 3; presenilin-1; FAD; PS1; S182; AD3; PS-1
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