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Anti-rgma Antibody Fab

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human rgma Antibody Fab Fragment MOM-18485-F(E) 1mg Please Inquiry
Product Detail
Cat
MOM-18485-F(E)
Product Overview
Recombinant Mouse Antibody Fab Fragment is directed against Human RGMA, expressed in Chinese Hamster Ovary cells(CHO)
Target
RGMA
Type
Fab
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Specificity
Tested positive against native antigen.
Purity
>95.0% as determined by analysis by RP-HPLC.
Storage
Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Background
Antigen Description
The Repulsive Guidance Molecule (RGM) family of proteins function as BMP co-receptors. It is hypothesized that RGM family members increase the sensitivity of cells in which they are expressed to BMP stimulation, thereby allowing these cells to respond earlier or more robustly to a low level of BMP ligand. RGM family members are an important addition to the complex array of regulatory molecules which help to generate specificity and tightly coordinate cellular responses to BMP ligands. RGM-A and RGM-B (DRAGON) are expressed in a complementary manner in the central nervous system; whilst RGM-A mediates repulsive axonal guidance and neural tube closure, DRAGON contributes to neuronal cell adhesion through homophilic interactions. RGMa also binds to the receptor neogenin and functions as a cell survival factor.
Gene ID
56963
Synonyms
RGMA; RGM domain family, member A; repulsive guidance molecule A; RGM
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