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Anti-robo4 Antibody

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human robo4 Antibody MOM-18486 1mg Please Inquiry
Product Detail
Cat
MOM-18486
Product Overview
Recombinant Mouse Antibody binds selectively to Human ROBO4, expressed in Chinese Hamster Ovary cells(CHO)
Target
ROBO4
Type
IgG
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in Neut, FuncS, IF, ICC and most other immunological methods.
Specificity
Tested positive against native antigen.
Purity
Purity >95% by SDS-PAGE.
Storage
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Background
Antigen Description
Robo4 is a vascular specific receptor that is a repulsive cue to migrating endothelial cells during vascular development. Guidance and patterning of axons are orchestrated by cell surface receptors and ligands that provide directional cues. Interactions between the Robo receptor and Slit ligand families of proteins initiate signaling cascades that repel axonal outgrowth. In contrast to known neuronal Robo family members, the arrangement of the extracellular domains of Robo4 diverges significantly from that of all other Robo family members. Robo4 is specifically expressed in the vascular endothelium during murine embryonic development; the only Robo family member expressed in primary endothelial cells. Robo4 also has a role in regulating the migration of endothelial cells during tumor angiogenesis.
Function
receptor activity;
Gene ID
54538
Synonyms
ROBO4; roundabout, axon guidance receptor, homolog 4 (Drosophila); roundabout homolog 4 (Drosophila); roundabout homolog 4; ECSM4; FLJ20798; magic roundabout; MRB; roundabout homolog 4, magic roundabout; MGC133352; MGC133353
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