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Anti-tshr Antibody Fab

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human tshr Antibody Fab Fragment MOM-18518-F(P) 1mg Please Inquiry
Product Detail
Cat
MOM-18518-F(P)
Product Overview
Recombinant Mouse Antibody Fab Fragment binds selectively to Human TSHR, expressed in E. coli
Target
TSHR
Type
Fab
Immunogen
Fusion protein, corresponding to amino acids 402-415 of Human TSH receptor.
Species Reactivity
Human
Expression Host
E. coli
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Specificity
Tested positive against native antigen.
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Background
Antigen Description
The TSH receptor, a G protein coupled seven transmembrane receptor, is present on the basal surface of thyroid follicular cells. It is involved in regulating thyrocyte cell growth and function by mediating thyroid stimulating hormone (TSH) action. The TSH receptor is also the target autoantigen in autoimmune thyroid diseases. Autoantibodies to the TSH receptor that stimulate cAMP production in thyrocyte cells, called thyroid stimulating antibodies, are responsible for the hyperthyroidism of Graves" Disease. Another class of autoantibodies that block the binding of TSH to the TSH receptor, thyroid blocking antibodies, may mediate the hypothyroidism associated with Hashimoto's thyroiditis, primary myxoedema, and neonatal hypothyroidism. Studies indicate that these autoantibodies interact primarily with the extracellular region of the TSH receptor. TSH receptor expression has been reported in adipose, adrenal, brain, eye, heart, kidney, skin, thymus, and thyroid. ESTs have been isolated from brain, placenta, and thyroid libraries.
Function
protein binding; receptor activity; signal transducer activity; thyroid-stimulating hormone receptor activity; thyroid-stimulating hormone receptor activity;
Gene ID
7253
Synonyms
TSHR; thyroid stimulating hormone receptor; thyrotropin receptor; LGR3; TSH-R; thyrotropin receptor-I, hTSHR-I; seven transmembrane helix receptor; thyroid-stimulating hormone receptor; thyroid stimulating hormone receptor, isoform 2; CHNG1; hTSHR-I; MGC75129
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