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Recombinant Anti-PADI2 Mab

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Human Anti-Human PADI2 Monoclonal Antibody HOM-19421 1mg Please Inquiry
Product Detail
Cat
HOM-19421
Product Overview
Recombinant humanized antibody expressed in CHO binding to human PADI2.
Target
PADI2
Type
Human IgG
Species Reactivity
Human
Expression Host
CHO
Applications
ELISA, WB, IHC, FCM, IP, IF. Optimal dilutions/concentrations should be determined by the end user.
Clone
Monoclonal
Molecular Weight
145.41 kDa
Purity
>95.0% as determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Storage
Store it under sterile conditions at -20 °C upon receiving. Recommend to pack the antibody into smaller quantities for optimal storage.
Stability
Samples are stable for up to twelve months from date of receipt at - °C and are stable for six months at 4 °C.
Ship
2-8°C, BLUE ICE
Background
Antigen Description
Protein-arginine deiminase type-2 is an enzyme that in humans is encoded by the PADI2 gene. This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.
Function
calcium ion binding; hydrolase activity; protein-arginine deiminase activity;
Gene ID
11240
Synonyms
PADI2; peptidyl arginine deiminase, type II; protein-arginine deiminase type-2; KIAA0994; PDI2; protein arginine deiminase; peptidylarginine deiminase II; peptidlyarginine deiminase type II; protein-arginine deiminase type II; PAD2; PAD-H19;
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