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Recombinant Anti-uPA Mab

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Human Anti-Human uPA Monoclonal Antibody HOM-19492 1mg Please Inquiry
Product Detail
Cat
HOM-19492
Product Overview
Recombinant humanized antibody expressed in CHO binding to human uPA.
Target
Plau
Type
Human IgG
Species Reactivity
Human
Expression Host
CHO
Applications
ELISA, WB, IHC, FCM, IP, IF. Optimal dilutions/concentrations should be determined by the end user.
Clone
Monoclonal
Molecular Weight
145.41 kDa
Purity
>95.0% as determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Storage
Store it under sterile conditions at -20 °C upon receiving. Recommend to pack the antibody into smaller quantities for optimal storage.
Stability
Samples are stable for up to twelve months from date of receipt at - °C and are stable for six months at 4 °C.
Ship
2-8°C, BLUE ICE
Background
Antigen Description
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell
migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's
disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by
specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to
form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the
catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular
weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into
a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the
uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Feb 2009)
Function
peptidase activity; protein binding; serine-type endopeptidase activity;
Gene ID
5328
Synonyms
PLAU; plasminogen activator, urokinase; urokinase-type plasminogen activator; UPA; URK; U-plasminogen activator; plasminogen activator, urinary; ATF; QPD; u-PA; BDPLT5;
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