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Recombinant Human Chemokine (C-C motif) ligand 16 /HCC-4

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Human Chemokine (C-C motif) ligand 16 /HCC-4 CRP08111 1mg Please Inquiry
Product Detail
Cat
CRP08111
Product Overview
Recombinant Human HCC-4/CCL16 produced in E. coli is a single, non-glycosylated polypeptide chain containing 97 amino acids and having a molecular mass of 11.2 kDa.
Specificity
Fully biologically active when compared to standard. Determined by its ability to chemoattract total human monocytes using a concentration range of 10.0 -100.0 ng/ml.
Endotoxin
Less than 1EU/mg of rHuHCC-4/CCL16 as determined by LAL method.
Purity
>97% by SDS-PAGE and HPLC analyses.
Storage
This lyophilized preparation is stable for several weeks at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.
Background
Antigen Description
Human HCC-4, also named NCC-4, liver-expressed chemokine (LEC), and lymphocyte and monocyte chemoattractant (LMC), is a novel CC chemokine identified through bioinformatics. HCC-4 cDNA encodes a 120 amino acid (aa) residue precursor protein with a 23 aa residue predicted signal peptide that is cleaved to generate a 97 aa residue mature protein. HCC-4 is distantly related to other CC chemokines, exhibiting less than 30% sequence identity. Among these CC chemokines, HCC-4 has the most similarity to HCC-1. Two potential polyadenylation signals are present on the human HCC-4 gene, and as a result, two transcripts containing approximately 1,500 base pairs and 500 base pairs have been detected. HCC-4 is expressed weakly by some lymphocytes, including NK cells, T cells, and some T cell clones. The expression of HCC-4 in monocytes is highly upregulated in the presence of IL-10.
Function
chemoattractant activity;chemokine activity.
Gene ID
6360
Synonyms
LEC; LMC; NCC4; CKb12; HCC-4; LCC-1; Mtn-1; NCC-4; SCYL4; ILINCK; SCYA16; MGC117051; CCL16_HUMAN; C-C motif chemokine 16 [Precursor]; Small-inducible cytokine A16;IL-10-inducible chemokine;Chemokine LEC;Liver-expressed chemokine;Monotactin-1;Chemokine CC-4;Lymphocyte and monocyte chemoattractant.
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