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Recombinant Human Chemokine (C-X-C motif) ligand 10 /IP-10

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Human Chemokine (C-X-C motif) ligand 10 /IP-10 CRP08112 1mg Please Inquiry
Product Detail
Cat
CRP08112
Product Overview
Recombinant Human IP-10/CXCL10 produced in E. coli is a single, non-glycosylated polypeptide chain containing 77 amino acids and having a molecular mass of 8.5 kDa.
Specificity
Fully biologically active when compared to standard. Determined by its ability to chemoattract human T-Lymphocytes using a concentration range of 10.0-100.0 ng/ml.
Endotoxin
Less than 1EU/μg of rHuIP-10/CXCL10 as determined by LAL method.
Purity
>97% by SDS-PAGE and HPLC analyses.
Storage
This lyophilized preparation is stable for several weeks at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation isstable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.
Recombinant Human Chemokine (C-X-C motif) ligand 10 /IP-10
PDB rendering based on 1o7z. Available structures: 1lv9,1o7y,1o7z,1o80
Background
Antigen Description
IP-10 was originally identified as an IFN-γ-inducible gene in monocytes, fibroblasts and endothelial cells. It has since been shown that IP-10 mRNA is also induced by LPS, IL-1β, TNF-α, IL-12 and viruses. Additional cell typesthat have been shown to express IP-10 include activated T-lymphocytes, splenocytes, keratinocytes, osteoblasts,astrocytes, and smooth muscle cells. IP-10 is also expressed in psoriatic and lepromatous lesions of skin. The mousehomologue of human IP-10, Crg-2, has been cloned andshown to share approximately 67% amino acid sequenceidentity with human IP-10.
Function
cAMP-dependent protein kinase regulator activity;chemokine activity
Gene ID
3627
Synonyms
C7;IFI10;INP10;IP-10;crg-2; CXL10_HUMAN;mob-1;SCYB10;gIP-10;Gamma-IP10 ;10 kDa interferon-gamma-induced protein; C-X-C motif chemokine 10 precursor; Small-inducible cytokine B10; chemokine (C-X-C motif) ligand 10; gamma IP10; interferon (gamma)-induced cell line; protein 10 from; interferon-inducible cytokine IP-10; protein 10 from interferon (gamma)-induced cell line; small inducible cytokine B10; small inducible cytokine subfamily B (Cys-X-Cys), member 10.
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