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Recombinant Human Glial Cell Line-Derived Neurotrophic Factor

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Human Glial Cell Line-Derived Neurotrophic Factor CRP0845 1mg Please Inquiry
Product Detail
Cat
CRP0845
Product Overview
Recombinant Human Glial Cell Line-Derived Neurotrophic Factor produced in E. coli has a molecular mass of approximately 15.2 KDa.
Purity
>95% as determined by SDS-PAGE.
Storage
Store at -80°C. Best use within three months from the date of receipt of this protein. Aliquot to avoid repeated freeze-thaw cycles.
Recombinant Human Glial Cell Line-Derived Neurotrophic Factor
PDB rendering based on 1ivo.
Background
Antigen Description
Glial cell-derived neurotrophic factor (GDNF) is a neurotrophic factor that is a member of the TGF-β superfamily. GDNF is founding member of the GDNF family of ligands, which to date include GDNF, neurturin (NTN), persephin (PSP) and artemin (ART). GDNF is a glycosylated disulfide-linked homodimeric protein of approximately 15 kDa. Mature rat and human GDNF share 93% sequence homology, with strong species cross-reactivity. GDNF promotes survival of various neuronal cells in central and peripheral nervous systems and different stages of development, including motoneurons, midbrain dopaminergic neurons, Purkinje cells and sympathetic neurons. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells. In addition,exogenously applied GDNF has been shown to rescue damaged facial motor neurons in vivo. Glial cell-derived neurotrophic factor is expressed in E. coli.
Function
growth factor activity, protein homodimerization activity
Gene ID
2668
Synonyms
ATF1; ATF2; HFB1-GDNF; ATF;hGDNF; Astrocyte- derived trophic factor; Glial cell line-derived neurotrophic factor precursor; astrocyte-derived trophic factor; glial cell derived neurotrophic factor; glial cell line derived neurotrophic factor; glial derived neurotrophic factor
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