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Recombinant Human Interferon-inducible T-cell alpha chemoattractant /CXCL11

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Human Interferon-inducible T-cell alpha chemoattractant /CXCL11 CRP08113 1mg Please Inquiry
Product Detail
Cat
CRP08113
Product Overview
Recombinant Human I-TAC/CXCL11 produced in E. coli is a single, non-glycosylated polypeptide chain containing 73 amino acids and having a molecular mass of 8.3 kDa.
Specificity
Fully biologically active when compared to standard. Determined by its ability to chemoattract human IL-2 activated T-Lymphocytes using a concentration range of 0.1-10.0 ng/ml.
Endotoxin
Less than 1EU/μg of rHuI-TAC/CXCL11 as determined by LAL method.
Purity
>97% by SDS-PAGE and HPLC analyses.
Storage
This lyophilized preparation is stable for several weeks at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation isstable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.
Recombinant Human Interferon-inducible T-cell alpha chemoattractant /CXCL11
PDB rendering based on 1rjt. Available structures: 1rjt
Background
Antigen Description
CXCL11 cDNA encodes a 94 amino acid (aa) residue precursor protein with a 21 aa residue putative signal sequence,which is cleaved to form the mature 73 aa residue protein. CXCL11 shares 36% and 37% amino acid sequence homology with IP-10 and MIG (two other known human non-ELR CXC chemokines), respectively. CXCL11 is expressed at low levels in normal tissues including thymus, spleen and pancreas. The expression of CXCL11 mRNA is radically up regulated in IFN-γ and IL-1 stimulated astrocytes. Moderate increase in expression is also observed in stimulated monocytes. CXCL11 has potent chemoattractant activity for IL-2 activated T cells and transfected cell lines expressing CXCR3, but not freshly isolated T-cells, neutrophils or monocytes.
Function
chemokine activity
Gene ID
6373
Synonyms
IP9; Beta-R1; H174; IP-9; b-R1; ITAC;I-TAC; SCYB11; SCYB9B; MGC102770; C-X-C motif chemokine 11 precursor;Human beta-R1 mRNA, partial cds; CXL11_HUMAN; chemokine (C-X-C motif) ligand 11;Interferon-gamma-inducible protein 9; Interferon-inducible T-cell alpha chemoattractant; Small-inducible cytokine B11; chemokine (C-X-C motif) ligand 11; small inducible cytokine B11; small inducible cytokine subfamily B (Cys-X-Cys), member 11; small inducible cytokine subfamily B (Cys-X-Cys), member.
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