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Recombinant Human Macrophage Inflammatory Protein 2-alpha

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Human Macrophage Inflammatory Protein 2-alpha CRP08145 1mg Please Inquiry
Product Detail
Cat
CRP08145
Product Overview
Recombinant Human MIG/CXCL9 produced in E. coli is a single, non-glycosylated polypeptide chain containing 103 amino acids and having a molecular mass of 11.7 kDa.
Specificity
Fully biologically active when compared to standard. Determined by its ability to chemoattract human peripheral blood T-Lymphocytes using a concentration range of 10.0-100.0 ng/ml.
Endotoxin
Less than 1EU/mg of rHuMIG/CXCL9 as determined by LAL method.
Purity
>97% by SDS-PAGE and HPLC analyses.
Storage
This lyophilized preparation is stable for several weeks at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.
Background
Antigen Description
CXCL9, a member of the α subfamily of chemokines that lack the ELR domain, was initially identified as a lymphokine-activated gene in mouse macrophages. The CXCL9 gene is induced in macrophages and in primary glial cells of the central nervous system specifically in response to IFN-γ. CXCL9 has been shown to be a chemoattractant for activated T-lymphocytes and TIL but not for neutrophils or monocytes. The human CXCL9 cDNA encodes a 125 amino acid residue precursor protein with a 22 amino acid residue signal peptide that is cleaved to yield a 103 amino acid residue mature protein. CXCL9 has an extended carboxy-terminus containing greater than 50% basic amino acid residues and is larger than most other chemokines. A chemokine receptor (CXCR3) specific for CXCL9 and IP-10 has recently been cloned and shown to be highly expressed in IL-2-activated T-lymphocytes.
Function
chemokine activity
Gene ID
4283
Synonyms
CMK; MIG; Humig; SCYB9; crg-10; Gamma-interferon-induced monokine; Small-inducible cytokine B9; chemokine (C-X-C motif) ligand 9; monokine induced by gamma interferon; small inducible cytokine B9; CXCL9_HUMAN; C-X-C motif chemokine 9 [Precursor]; Gamma-interferon-induced monokine.
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