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Recombinant Human Macrophage inflammatory protein 3 alpha /CCL20

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Human Macrophage inflammatory protein 3 alpha /CCL20 CRP08115 1mg Please Inquiry
Product Detail
Cat
CRP08115
Product Overview
Recombinant Human MIP-3 alpha/CCL20 produced in E. coli is a single, non-glycosylated polypeptide chain containing 70 amino acids and having a molecular mass of 8.0 kDa.
Specificity
Fully biologically active when compared to standard. Determined by its ability to chemoattract human T lymphocytes using a concentration range of 10.0 -50.0 ng/ml.
Endotoxin
Less than 1EU/μg of rHuMIP-3a/CCL20 as determined by LAL method.
Purity
>97% by SDS-PAGE and HPLC analyses.
Storage
This lyophilized preparation is stable for several weeks at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.
Recombinant Human Macrophage inflammatory protein 3 alpha /CCL20
PDB rendering based on 1m8a.Available structures: 1m8a, 2hci
Background
Antigen Description
MIP-3 alpha/CCL20, also known as LARC (Liver and Activation-regulated Chemokine) and as Exodus, is a CC chemokine that is expressed in the liver, lymph nodes, appendix, PBL and lung and can signal through the CCR6 receptor. MIP-3 alpha is chemotactic towards lymphocytes and dendritic cells. Additionally, it promotes the adhesion of memory CD4+ T cells and inhibits colony formation of bone marrow myeloid immature progenitors.
Function
chemokine activity.
Gene ID
6364
Synonyms
CKb4; LARC; exodus-1; MIP-3-alpha ; ST38; MIP3A; MIP-3a; SCYA20; Beta chemokine exodus-1; C-C motif chemokine 20 precursor; chemokine (C-C motif) ligand 20; CC chemokine LARC; CCL20_HUMAN; Human mRNA for CC chemokine LARC precursor, complete cds; Liver and activation-regulated chemokine; Macrophage inflammatory protein 3 alpha; Small-inducible cytokine A20; chemokine (C-C motif) ligand 20; small inducible cytokine subfamily A (Cys-Cys), member 20.
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