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Recombinant Human Osteoprotegerin/Fc Chimera

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Human Osteoprotegerin/Fc Chimera CRP0892 1mg Please Inquiry
Product Detail
Cat
CRP0892
Product Overview
Recombinant human OPG/Fc produced in Pichia. P. contains 412 amino acid residues, including 180 residues from mature OPG (a.a 22-201) and 232 residues from the Fc protein of human IgG1, and has a calculated molecular mass of 46.5 kDa. As a result of glycosylation, the recombinant OPG/Fc migrates as a 49 kDa protein in SDS-PAGE under reducing conditions.
Specificity
Fully biologically active when compared to the standard. Determined by its ability to neutralize the stimulation of U937 cells treated with 10 ng/ml of soluble RANKL.
Endotoxin
Less than 1EU/μg of rHuOPG-Fc as determined by LAL method.
Purity
>90% by SDS-PAGE and HPLC analyses.
Storage
This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤20°C. Further dilutions should be made in appropriate buffered solutions.
Background
Antigen Description
Osteoprotegerin (OPG) is a member of the TNFR superfamily that can act as a decoy receptor for RANKL. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. OPG is expressed in a wide variety of tissues including adult heart, lung, kidney, liver, spleen, prostate, lymph node and bone marrow. OPG is secreted both as a monomeric and a dimeric protein. Its primary structure consists of seven distinct domains, four of which corresponds to the extracellular cysteine-rich domains of TNFR proteins and constitutes the soluble OPG.
Function
cytokine activity; protein binding; receptor activity
Gene ID
4982
Synonyms
OPG; TR1; OCIF; MGC29565; Osteoprotegerin; osteoclastogenesis inhibitory factor; Tumor necrosis factor receptor superfamily member 11B; Tumor necrosis factor receptor superfamily member 11B Precursor
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