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Recombinant Human Parathyroid Hormone 1-34

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Human Parathyroid Hormone 1-34 CRP0864 1mg Please Inquiry
Product Detail
Cat
CRP0864
Product Overview
Recombinant Human Parathyroid Hormone 1-34 produced in E. coli is a single, non-glycosylated Polypeptide chain containing 34 amino acids and having a molecular mass of 4117.8 Da.
Specificity
Fully biologically active when compared to standard. The activity calculated by UMR106 cell/cAMP method corresponding to a specific activity of 1.0 x 104 Units/mg.
Endotoxin
Less than 1EU/mg of rHuPTH1-34 as determined by LAL method.
Purity
>97% by SDS-PAGE and HPLC analyses.
Storage
This lyophilized preparation is stable for several weeks at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤20°C. Further dilutions should be made in appropriate buffered solutions.
Recombinant Human Parathyroid Hormone 1-34
PDB rendering based on 1bwx.
Background
Antigen Description
Polypeptide hormones secreted by the parathyroid glands, which promote release of calcium from bone to extracellular fluid by activating osteoblasts and inhibiting osteoclasts, indirectly promote increased intestinal absorption of calcium, and promote renal tubular reabsorption of calcium and increased renal excretion of phosphates. It is a major regulator of bone metabolism. Secretion of parathyroid hormone increases when the level of calcium in the extracellular fluid is low. Its action is opposed by calcitonin.
Function
hormone activity; parathyroid hormone receptor binding activity
Gene ID
5741
Synonyms
parathormone; parathyrin; Parathyroid hormone precursor; parathyroid hormone
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