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Recombinant Human Pigment Epithelium-derived Factor

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Human Pigment Epithelium-derived Factor CRP0870 1mg Please Inquiry
Product Detail
Cat
CRP0870
Product Overview
Recombinant Human Pigment Epithelium-derived Factor produced in E.coli is a single non-glycosylated polypeptide chain containing 400 amino acids and having a molecular mass of approximately 44.5KDa.
Endotoxin
Less than 1EU/mg of rHuPEDF as determined by LAL method
Purity
>95% by SDS-PAGE and HPLC analyses.
Storage
This lyophilized preparation is stable for several weeks at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.
Recombinant Human Pigment Epithelium-derived Factor
PDB rendering based on 1imv.
Background
Antigen Description
PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member.
Function
serine-type endopeptidase inhibitor activity
Gene ID
5176
Synonyms
EPC-1, PEDF, PIG35, Serpin-F1;pigment epithelium-derived factor; proliferation-inducing protein 35; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; Pigment epithelium-derived factor precursor; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
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