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Recombinant Human Tumor necrosis factor alpha

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Human Tumor necrosis factor alpha CRP0806 1mg Please Inquiry
Product Detail
Cat
CRP0806
Product Overview
Tumor necrosis factor alpha-1a or TNFalpha-1a is a non-glycosylated cytokine produced from E. coli using rDNA technology. The protein consists of three identical polypeptide chains of 158 amino acids combined to form a compact, bell-shaped homotrimer. The individual subunits have a relative molecular mass each of 17.484 kDa.
Specificity
The ED50 as determined by the cytolysis of murine L929 cells in the presence of Actinomycin D is less than 0.03ng/ml, corresponding to a Specific Activity of 3.0 x 107 IU/mg.
Endotoxin
Less than 0.01ng/ug (0.01IEU/ug) determined by LAL test.
Purity
>95% by SDS-PAGE and SEC-HPLC .
Storage
Lyophilized samples are stable for up to twelve months from date of receipt at -20oC to -70oC. Aliquot to avoid repeated freeze-thaw cycles.
Reconstitution
It is recommended to reconstitute the lyophilized TNF alpha-1a in sterile 18MΩ-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.
Recombinant Human Tumor necrosis factor alpha
PDB rendering based on 1TNF.
Background
Antigen Description
TNF-alpha is a homotrimer with a subunit molecular mass of 17 kDa and that it plays a major role in growth regulation, differentiation, inflammation, viral replication, tumorigenesis, and autoimmune diseases; and in viral, bacterial, fungal, and parasitic infections. Besides inducing hemorrhagic necrosis of tumors, TNF was found to be involved in tumorigenesis, tumor metastasis, viral replication, septic shock, fever, inflammation, and autoimmune diseases including Crohn’s disease, and rheumatoid arthritis as well as graft-versus-host disease.
Function
Cytokine activity, Identical protein binding, Tumor necrosis factor receptor binding
Gene ID
7124
Synonyms
DIF; TNFA; TNFSF2; TNF-alpha; Tumor necrosis factor precursor; TNF-alpha; TNF-α; Tumor necrosis factor ligand superfamily member 2; Cachectin
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