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Recombinant Human Ubiquitin Conjugating Enzyme 9 (His6-tagged)

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Human Ubiquitin Conjugating Enzyme 9 (His6-tagged) CRP08136 1mg Please Inquiry
Product Detail
Cat
CRP08136
Product Overview
Recombinant Human Ubiquitin Conjugating Enzyme 9 produced in E.coli is a single non-glycosylated polypeptide chain containing 171 amino acids and having a molecular mass of approximately 19.5 kDa.
Endotoxin
Less than 1EU/μg of rHuUbc9 as determined by LAL method.
Purity
>95% by SDS-PAGE and HPLC analyses.
Storage
This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.
Recombinant Human Ubiquitin Conjugating Enzyme 9 (His6-tagged)
PDB rendering based on 1a3s.Available structures: 1a3s, 1kps, 1u9a, 1u9b, 1z5s2grn,2gro,2grp,2grq,2grr,2o25,2pe6
Background
Antigen Description
Human Ubquitin Conjugating Enzyme 9 (Ubc9) is a member of the E2 family and is specific for the conjugation of SUMO to a variety of target proteins. SUMO conjugation to target proteins is mediated by a different, but analogous, pathway to ubiquitinylation. This E2 is unusual in that it interacts directly with protein substrates that are modified by sumolyation, and may play a role in substrate recognition. Ubc9 can mediate the conjugation of SUMO-1 to a variety of proteins including RanGAP1, IκBα, and PML without the requirement of an E3 ligase.
Function
HLH domain binding;ligase activity;protein binding; small conjugating protein ligase activity.
Gene ID
7329
Synonyms
P18; UBC9; C358B7.1; ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast); ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9); UBC9_HUMAN; SUMO-conjugating enzyme UBC9; EC 6.3.2.-; SUMO-protein ligase; Ubiquitin-protein ligase I; Ubiquitin carrier protein I; Ubiquitin carrier protein 9; UBE2I;UBCE9; Ubiquitin-protein ligase I; ubiquitin carrier protein; ubiquitin conjugating enzyme 9; ubiquitin-conjugating enzyme E2I; ubiquitin-conjugating enzyme UbcE2A; ubiquitin-like protein SUMO-1 conjugating enzyme.
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