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Recombinant Human beta-Defensin 1

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Human beta-Defensin 1 CRP0866 1mg Please Inquiry
Product Detail
Cat
CRP0866
Product Overview
Recombinant Human beta-Defensin 1 produced in E. coli isa single non-glycosylated polypeptide chain containing 47 amino acids and having a molecular mass of approximately 5.0 KDa,.
Specificity
Fully biologically active when compared to standard. Determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 0.1-1.0 ug/ml.
Endotoxin
Less than 1EU/mg of rHuBD-1 as determined by LAL method.
Purity
>98% by SDS-PAGE and HPLC analyses.
Storage
This lyophilized preparation is stable for several weeks at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.
Recombinant Human beta-Defensin 1
PDB rendering based on 1e4s.
Background
Antigen Description
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, four human β-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. β-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues.
Gene ID
1672
Synonyms
BD1; DEFB-1; DEFB101; HBD1; hBD-1; beta-defensin-1; defensin beta 1; MGC51822; Beta-defensin 1 precursor; BD-1
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