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Recombinant Mouse Interferon-γ

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Mouse Interferon-γ CRP0897 1mg Please Inquiry
Product Detail
Cat
CRP0897
Product Overview
Recombinant Mouse Interferon-γ produced in E. coli is a single non-glycosylated polypeptide chain containing 134 amino acids and having a molecular mass of 15.6 kDa.
Specificity
Fully biologically active when compared to standard. The specific activity as determined in a viral resistance assay is less than 0.1 ng/ml, corresponding to a specific activity of 1.0×107 IU/ mg.
Endotoxin
Less than 1EU/mg of rmIFN-γ as determined by LAL method.
Purity
>95% by SDS-PAGE and HPLC analyses.
Storage
This lyophilized preparation is stable for several weeks at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤20°C. Further dilutions should be made in appropriate buffered solutions.
Recombinant Mouse Interferon-γ
Interferon gamma, Available structures:1eku, 1fg9, 1fyh, 1hig
Background
Antigen Description
Interferon-gamma (IFN-γ, also known as Type II interferon or immune interferon) is a cytokine produced primarily by T-lymphocytes and natural killer cells. The protein shares no significant homology with IFN-β or the various IFN-α family proteins. Mature IFN-γ exists as noncovalently-linked homodimers. Human IFN-γ is highly species specific and is biologically active only in human and primate cells. IFN-γ was originally characterized based on its antiviral activities. The protein also exerts antiproliferative, immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms. IFN-γ induces the production of cytokines, upregulates the expression of class I and II MHC antigens, Fc receptor and leukocyte adhesion molecules. It modulates macrophage effector functions, influences isotype switching and potentiates the secretion of immunoglobulins by B cells. IFN-γ also augments TH1 cell expansion and may be required for TH1 cell differentiation.
Function
cytokine activity; interferon-gamma receptor binding
Gene ID
15978
Synonyms
Ifg; IFN-g; IFN-gamma; Immune Interferon; type II interferon; T cell interferon; MAF; IFNG; IFG; IFI; gamma interferon
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