Follow us on:
Dedication / Services
To provide 50000 services and products to global scientific research units every year

Recombinant Mouse Interleukin-22

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Mouse Interleukin-22 CRP0833 1mg Please Inquiry
Product Detail
Cat
CRP0833
Product Overview
Recombinant Mouse IL-22 produced in E. coli is a single, non-glycosylated polypeptide chain containing 147 amino acids and having a molecular mass of 16.7 kDa.
Specificity
Recombinant Mouse IL-22 is fully biologically active when compared to standard. The ED50 as determined by its ability to induce IL-10 secretion in Colo205 cells is less than 0.5ng/ml, corresponding to a Specific Activity of 2.0 x 106 IU/mg.
Endotoxin
Less than 0.1ng/ug (1 IEU/ug) determined by LAL test.
Purity
>97% as determined by RP-HPLC and SDS-PAGE.
Storage
Lyophilized rmIL-22 although stable at room temperature for 3 weeks, should be stored desiccated below -18oC. Upon reconstitution rmIL-22 should be stored at 4oC between 2-7 days and for future use below -18oC. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Aliquot to avoid repeated freeze-thaw cycles.
Reconstitution
It is recommended to reconstitute the lyophilized rmIL-22 in sterile 18MΩ-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.
Recombinant Mouse Interleukin-22
Crystal structure of IL-22.
Background
Antigen Description
Interleukin-22 (IL-22), also known as IL-10-related T cell-derived inducible factor (IL-TIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. Mouse IL-22 cDNA encodes a 179 amino acid (aa) residue protein with a putative 33 aa signal peptide that is cleaved to generate a 147 aa mature protein that shares approximately 79% and 22% aa sequence identity with human IL-22 and IL-10, respectively. IL-22 has been shown to activate STAT-1 and STAT-3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal mouse T cells upon Con A activation. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R (previously an orphan receptor named CRF2-9) and IL-10Rβ (previously known as CRF2-4), belonging to the class II cytokine receptor family.
Function
cytokine activity; protein binding
Gene ID
50929
Synonyms
IL-22, IL-TIF, Iltif, TIFa, IL-10-related T-cell-derived-inducible factor, ILTIFA, IL-D110, zcyto18, MGC79382, MGC79384, TIFIL-23, Interleukin-22, IL-TIF alpha, Interleukin-22a, IL-22a, Interleukin-22 Precursor
Download Datasheet:

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

Online Inquiry
Please input "biolabs"(case insensitive) as verification code.
Loading...
Contact Us

USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email: 

Europe
Tel: 44-207-048-3343


© 2007 - 2017 Creative-Biolabs All Rights Reserved