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Recombinant Ovine Interferon-tau

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Ovine Interferon-tau CRP08103 1mg Please Inquiry
Product Detail
Cat
CRP08103
Product Overview
Recombinant Ovine Interferon-tau produced in Pichia. P is a single non-glycosylated polypeptide chain containing 172 amino acids and having a molecular mass of approximately 20 kDa,
Specificity
Fully biologically active when compared to IFN-alpha. The specific activity as determined in a viral resistance assay was found to be no less than 1.0 x 107IU/mg.
Endotoxin
Less than 1EU/μg of rOvIFN-tau as determined by LAL method.
Purity
>95% by SDS-PAGE and HPLC analyses.
Storage
This lyophilized preparation is stable for several weeks at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.
Background
Antigen Description
IFN-tau is a new class of type I IFN that is secreted by the trophoblast and is the signal for maternal recognition of pregnancy in sheep. IFN- tau has potent immunosuppressive and antiviral activities similar to other type I IFN but isless cytotoxic than IFN-α/β. The current investigation concerns the effect of recombinant ovine IFN- tau (rOvIFN-tau) on the modulation of MHC class I and II expression on cloned mouse cerebrovascular endothelial (CVE) cells.IFN- tau induced tyrosine phosphorylation of Stat1 and upregulated the expression of MHC class I on CVE. Oneproposed action by which type I IFN reduce the relapse rate in MS is via interference with IFN-γ-induced MHC class II expression. IFN- tau was shown to downregulate IFN-γ-induced MHC class II expression on CVE and,hence, may be of potential therapeutic value in downregulating inflammation in the central nervous system (CNS). IFN- tau did not upregulate the expression of MHC class II on CVE. IFN- tau also inhibited the replication of Theiler's virus in CVE.
Gene ID
100144750
Synonyms
Interferon-tau;TP-1; TP-1 trophoblast protein-1 ; Trophoblastin;Antiluteolysin;Trophoblast antiluteolytic protein; OTP; IFNT1; IFNT4; Interferon tau-1; Interferon tau-4
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