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Recombinant rat interleukin-10

DESCRIPTION CATALOG # SIZE PRICE
Recombinant rat interleukin-10 CRP08104 1mg Please Inquiry
Product Detail
Cat
CRP08104
Product Overview
Recombinant rat interleukin-10 produced in E. coli is a single non-glycosylated polypeptide chain containing 160 amino acids and having a molecular mass of approximately 18.7 kDa.
Specificity
Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent inhibition of antigen-specific T cell proliferation is less than 10ng/ml.
Endotoxin
Less than 1EU/μg of rrIL-10 as determined by LAL method.
Purity
>95% by SDS-PAGE and HPLC analyses.
Storage
This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long termstorage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into workingaliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.
Recombinant rat interleukin-10
PDB rendering based on 2H24
Background
Antigen Description
IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells.
Function
cytokine activity; interleukin-10; receptor binding; protein binding
Gene ID
25325
Synonyms
interleukin 10; IL10X, CSIF; IL-10; IL10A; MGC126450; MGC126451; TGIF; B-TCGF; Cytokine synthesis inhibitory factor; Interleukin-10 precursor
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