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Protein A Scaffold

Protein A scaffold molecules are engineered binding proteins for therapeutic, diagnostic and biotechnological applications, which bind to a wide range of protein targets. Protein A scaffold molecules are small (6.5 kDa) non-immunoglobulin affinity ligands based on a 58-amino-acid Z-domain scaffold, derived from one of the IgG-binding domains of staphylococcal protein A.

Protein A Scaffolds,Recombinant Antibodies - Creative Biolabs
Key Advantages
• multi-specific formats
• ability to fold correctly intracellularly
• site-specifically modified drug conjugates
• biodistribution flexibility
• good tissue penetration

Creative biolabs has created a large library consisting of more than ten billion Protein A scaffold molecules, all with unique binding sites, from which binders to given targets are selected.


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