Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsCreative Biolabs offers specialized thermal stable antibody fragment (scFv/Fab) screening and antibody stability improvement services. With 10 years of experience in antibody engineering and therapeutic antibody development, scientists of Creative Biolabs hold unparalleled expertise in phage display and yeast display scFv/Fab library construction and screening for thermodynamic properties such as thermal stability using high throughput approaches.
Fig. 1 Antibody, Fab and scFv. (Blein and Hou 2012)
Stability is one of the most important functional requirements for the use of antibodies and antibody fragments in therapeutic and diagnostic applications. However, the non-ideal biophysical properties and insufficient thermal stability of antibody fragments such as scFv and Fab often leads to poor expression level, poor solubility and protein aggregation, which limits their potential as diagnostic and therapeutic agents. To fulfill our customers’ requirements, Creative Biolabs’ optimized strategies enable separation and screening of properly folded, active antibody fragments from culture supernatants under ordinary and “challenge” temperatures simultaneously. After that, antibody fragments that reach the target stability as measured by melting temperature (Tm) can be identified. We normally obtain thermal stable Fab fragments with Tm at 70°C or higher in most of our screening projects.
Besides screening for thermal stable scFv/Fab fragments, scientists at Creative Biolabs have also developed a unique engineering strategy for stability improvement of antibody and antibody fragments.
Reference
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
