Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsIn terms of our years’ experience in single domain antibody realm, Creative Biolabs is able to assist our global clients in discovering and developing unique anti-albumin sdAbs with high specificity and affinity. Through our advanced phage display platform and comprehensive developability evaluations and selections, our scientists are confident in offering high-quality anti-albumin sdAbs exhibit efficient properties with high purity and yield.
Single domain antibody (sdAb), also known as domain antibody (dAb), is an antibody fragment generally derived from the novel heavy chain antibody (camelid) or IgNAR (cartilaginous fishes). A single domain antibody consists of the variable domain of heavy chain (VHH of heavy chain antibody, VNAR of IgNAR, or even VH/VL domain of conventional antibody) with a significantly smaller size than conventional antibodies. Compared with the traditional antibody, the CDR3 region of natural single domain antibody is longer, and the disulfide bond can form a larger antigen-binding loop with the adjacent CDR region, thereby increasing the binding area of the single domain antibody to the antigen. Not only that, single domain antibodies have better tissue permeability and lower immunogenicity due to its smaller size and extreme stability. Based on these advantages, single domain antibody has contributed to a series of fantastic applications in immunoassay, diagnostics, and therapeutics, especially as a potential component in drug discovery and development pipeline. With extensive experience in sdAb discovery and development field, scientists from Creative Biolabs are pleased to assist our clients to own their novel sdAb with high affinity and specificity to their interest targets, especially for the human serum albumin.
As one of the popular biomarkers in drug discovery, human serum albumin has widely distributed in the human body and has good stability and long half-life in serum. According to its properties, the human serum albumin plays important roles in the detection and diagnosis of diseases, such as diabetes, kidney disease, and cardiovascular disease. Meanwhile, the human serum albumin is also a well-validated fusion partner with other therapeutic agents. It can be coupled with drugs by fusion expression, covalent coupling, and non-covalent coupling to improve drug efficacy and half-life. The interaction mechanism between FcRn and albumin is of great significance to the pharmacokinetics and pharmacodynamics of albumin carrier drugs.
Scientists from Creative Biolabs can tailor our advanced platform to generate novel anti-albumin sdAbs to meet our clients’ specific project objectives. Fusion with an anti-albumin sdAb is a potential option to extend the serum half-life of therapeutic agents. The well-developed anti-albumin sdAb will recognize the albumin after properly administration and allow the fused biopharmaceutical agent to be carried around the body, and to take on similar PK parameters with the albumin as well.
Typical Workflow for Anti-Albumin sdAb Discovery
After the discovery of specific anti-albumin sdAbs, our scientists can then offer a series of development services to further characterize and improve the application of anti-albumin sdAbs, which including but not limited to antibody affinity measurement, sdAb affinity maturation, immunogenicity assessment, manufacturability assessment, human or humanized sdAb production, and bispecific sdAb development.
Based on our state-of-the-art technology and expertise, Creative Biolabs are specialized in the discovery and production of anti-albumin single domain antibodies. Our scientists are pleased to offer customized service to meet our clients’ the most specific demands. If you are interested in developing the novel anti-albumin sdAbs, please do not hesitate to inquire us for more details.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
