Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsScientists from Creative Biolabs have successfully produced all three types of bispecific antibodies using well-established methods. According to customer's detailed requirements, Creative Biolabs will design and perform the most suitable approach to fulfil client's demands.
Fig. 1. Various types of bispecific antibodies (Kontermann 2015)
Of the two paratopes that form the tops of the variable domains in bispecific antibody, one can be directed against a tumour antigen and the other against a T lymphocyte antigen like CD3. In the case of trifunctional antibodies, the intact Fc region additionally binds to a cell that expresses Fc receptors like macrophage, a natural killer cell or a dendritic cell. In summary, through bispecific antibody, the tumour cell is connected to one or two cells of the immune system, leading to their destruction.
Comparing to the ordinary monoclonal antibodies, the ordinary ones can't activate T lymphocytes. Because there are no Fc receptors on T lymphocytes, the Fc region of ordinary monoclonal antibody can't bind to them, and the Fab regions are already used for binding the tumour cells. As a result, the bispecific antibody shows advantage in cancer immunotherapy over ordinary monoclonal antibody. Besides, bispecific antibodies have a higher cytotoxic potential. They are able to bind antigen that are expressed relatively weakly. It's common that bispecific antibody can have an effective dose several orders of magnitude lower than ordinary antibodies.
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