anti-AURKA (aa 207-215) TCR, pCDTCR1(TCR-L004Z)

The vector of anti-AURKA T cell receptor (TCR) is constructed for the engineering of T cell to target Human AURKA. The T cells are genetically modified through transduction with a retroviral vector expressing AURKA-specific T cell receptor. And the vector product was designed for the treatment of leukemia.


Details


Target
AURKA
Target Species
Human
Epitope
YLILEYAPL
Format
Non-modified TCR
HLA
HLA-A*0201
Targeting Diseases
Leukemia
Vector Name
pCDTCR1
Vector Length
8kb
Vector Type
Lentiviral vector
Antibody Host
Human

Target


Gene Name
aurora kinase A
Official Symbol
AURKA
Gene ID
UniProt ID
Synonyms
AIK; ARK1; AURA; BTAK; STK6; STK7; STK15; AURORA2; PPP1R47; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Leukemia
Introduction
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products


Leukemia

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