anti-CEACAM5 TCR, pLXSN(TCR-L010)

The vector of anti-CEACAM5 T cell receptor (TCR) is constructed for the engineering of T cell to target Human CEACAM5. The T cells are genetically modified through transduction with a retroviral vector expressing CEACAM5-specific T cell receptor. And the vector product was designed for the treatment of Colorectal cancer.


Details


Target
CEACAM5
Target Species
Human
Epitope
IMIGVLVGV
Format
Codon optimized TCR
HLA
HLA-A2
Targeting Diseases
Colorectal cancer
Vector Name
pLXSN
Vector Length
6714-6688bp
Vector Type
retroviral vector
Antibody Host
Mouse

Target


Gene Name
carcinoembryonic antigen related cell adhesion molecule 5
Official Symbol
CEACAM5
Gene ID
UniProt ID
Synonyms
CEA; CD66e; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Colorectal cancer
Introduction
This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products


Carcinoma

Online Inquiry

Name:
Phone:
*E-mail Address:
*Service & Products Interested:
Project Description:
*Verification Code:
Please input "biolabs"(case insensitive) as verification code.
CB Promise
CONTACT US
45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-871-5806
Europe: 44-207-048-3343
Fax: 1-631-207-8356
Email:
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-048-3343

Distributors

To view the contact information for a specific location, select the desired country:

Australia
australia

FOLLOW US ON