anti-gag TCR, pGMT7(TCR-L019)
The vector of anti-gag T cell receptor (TCR) is constructed for the engineering of T cell to target HIV gag. The T cells are genetically modified through transduction with a retroviral vector expressing gag-specific T cell receptor. And the vector product was designed for the treatment of ADIS.
FrMLVgp1; gag; gag protein; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; viral infection
HIV1 p15(Gag) and its protease cleavage products, nucleocapsid protein p7 and p6, are believed to play a major role in viral infectivity and assembly during the early and late stages of retroviral life cycle. p15 is frequently recognized by HIV1-specific CD8+T cells in natural HIV1 infection and may be an important target for the design of future HIV1 vaccines.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.