anti-gp100 TCR, pGMT7(TCR-L029)

The vector of anti-gp100 T cell receptor (TCR) is constructed for the engineering of T cell to target Human gp100. The T cells are genetically modified through transduction with a retroviral vector expressing gp100-specific T cell receptor. And the vector product was designed for the treatment of melanoma.


Details


Target
gp100
Target Species
Human
Epitope
YLEPGPVTA
Format
Affinity enhanced
HLA
HLA-A2
Targeting Diseases
Melanoma
Vector Name
pGMT7
Vector Length
3111bp
Vector Type
retroviral vector
Antibody Host
Human

Target


Gene Name
premelanosome protein
Official Symbol
PMEL17
Gene ID
UniProt ID
Synonyms
PMEL; premelanosome protein; SIL, SILV, silver (mouse homolog) like , silver homolog (mouse); melanocyte protein PMEL; D12S53E; gp100; Pmel17; SI; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Melanoma
Introduction
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Carcinoma

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