anti-gp160 TCR, pMSGV1(TCR-L033)

The vector of anti-gp160 T cell receptor (TCR) is constructed for the engineering of T cell to target HIV gp160 . The T cells are genetically modified through transduction with a retroviral vector expressing gp160 -specific T cell receptor. And the vector product was designed for the treatment of AIDS.


Details


Target
gp160
Target Species
HIV
Epitope
RGPGRAFVTI
Format
Non-modified TCR
Targeting Diseases
AIDS
Vector Name
pMSGV1
Vector Length
6700-8070bp
Vector Type
retroviral vector
Antibody Host
Mouse

Target


Gene Name
gp160; envelope glycoprotein
Official Symbol
env
Gene ID
UniProt ID
Synonyms
HIV-1 envelope glycoprotein (Env); Human immunodeficiency virus-1 envelope glycoprotein (Env); human immunodeficiency virus; HIV; Retroviridae; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; AIDS; HIV
Introduction
The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes the
acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of
the immune system allows life-threatening opportunistic infections and cancers to thrive. Without
treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending
on the HIV subtype. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, preejaculate,
or breast milk. Within these bodily fluids, HIV is present as both free virus particles and
virus within infected immune cells.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Viral Infection

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Fax: 1-631-207-8356
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