anti-HBP TCR, pMSGV1(TCR-L054)

The vector of anti-HBP T cell receptor (TCR) is constructed for the engineering of T cell to target Human HBP. The T cells are genetically modified through transduction with a retroviral vector expressing HBP-specific T cell receptor. And the vector product was designed for the treatment of multiple sclerosis.


Details


Target
HBP
Target Species
Human
Epitope
DENPWHFFKNIVTPRTPP
Format
Non-modified TCR
HLA
HLA-DR3
Targeting Diseases
Multiple sclerosis (MS)
Vector Name
pMSGV1
Vector Length
6700-8070bp
Vector Type
retroviral vector
Antibody Host
Human

Target


Gene Name
myelin basic protein
Official Symbol
MBP
Gene ID
UniProt ID
Synonyms
MBP; Myelin A1 Protein; Myelin Basic Protein; Myelin Membrane Encephalitogenic Protein; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Multiple sclerosis; MS
Introduction
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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