anti-HDV TCR, pMSGV1(TCR-L048)

The vector of anti-HDV T cell receptor (TCR) is constructed for the engineering of T cell to target HDV. The T cells are genetically modified through transduction with a retroviral vector expressing HDV-specific T cell receptor. And the vector product was designed for the treatment of HDV infection.


Details


Target
HDV
Target Species
HDV
Format
Non-modified TCR
HLA
HLA-A2
Targeting Diseases
HDV infection
Vector Name
pMSGV1
Vector Length
6700-8070bp
Vector Type
retroviral vector
Antibody Host
Human

Target


Gene Name
Hepatitis D Virus
Official Symbol
HDV
Synonyms
delta virus; Deltavirus; HDV; Hepatitis D virus; Hepatitis delta virus; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; HDV infection
Introduction
The hepatitis delta virus (HDV) is distributed worldwide and related to the most severe form of viral hepatitis. HDV is a satellite RNA virus dependent on hepatitis B surface antigens to assemble its envelope and thus form new virions and propagate infection. HDV has a small 1.7 Kb genome making it the smallest known human virus. This deceivingly simple virus has unique biological features and many aspects of its life cycle remain elusive. The present review endeavors to gather the available information on HDV epidemiology and clinical features as well as HDV biology.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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