anti-HER2 (aa368-377) TCR, pCDTCR1(TCR-L050Z)

The vector of anti-HER2 T cell receptor (TCR) is constructed for the engineering of T cell to target Human HER2. The T cells are genetically modified through transduction with a retroviral vector expressing HER2-specific T cell receptor. And the vector product was designed for the treatment of breast cancers.


Details


Target
HER2
Target Species
Human
Epitope
KIFGSLAFL
Format
Non-modified
HLA
HLA-A2
Targeting Diseases
Breast cancer
Vector Name
pCDTCR1
Vector Length
8kb
Vector Type
Lentiviral
Antibody Host
Human

Target


Gene Name
erb-b2 receptor tyrosine kinase 2
Official Symbol
ERBB2
Gene ID
UniProt ID
Synonyms
NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu
Introduction
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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