anti-HER2 TCR, pMSGV(TCR-L050)

The vector of anti-HER2 T cell receptor (TCR) is constructed for the engineering of T cell to target Human HER2. The T cells are genetically modified through transduction with a retroviral vector expressing HER2-specific T cell receptor. And the vector product was designed for the treatment of breast, ovary, stomach, kidney, colon, and lung cancer.


Details


Target
HER2
Target Species
Human
Epitope
ErbB2 369–377
Format
Non-modified TCR
HLA
HLA-A2
Targeting Diseases
Breast, ovary, stomach, kidney, colon, and lung cancers
Vector Name
pMSGV
Vector Length
6700bp
Vector Type
retroviral vector
Antibody Host
Human

Target


Gene Name
erb-b2 receptor tyrosine kinase 2
Official Symbol
ERBB2
Gene ID
UniProt ID
Synonyms
Human papillomavirus; HPV; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Melanoma
Introduction
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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