anti-LMP2 TCR, pMP71(TCR-L057)

The vector of anti-LMP2 T cell receptor (TCR) is constructed for the engineering of T cell to target EBV LMP2. The T cells are genetically modified through transduction with a retroviral vector expressing LMP2-specific T cell receptor. And the vector product was designed for the treatment of EBV infection.


Details


Target
LMP2
Target Species
EBV
Epitope
CLGGLLTMV
Format
Non-modified TCR
HLA
HLA-A0201
Targeting Diseases
EBV infection
Vector Name
pMP71
Vector Length
3817bp
Vector Type
retroviral vector
Antibody Host
Human

Target


Gene Name
EBNA3A nuclear protein
Official Symbol
LMP2
Gene ID
UniProt ID
Synonyms
LMP2; EBNA3A nuclear protein; EBNA3A; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; EBV infection
Introduction
Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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CarcinomaLymphomaViral Infection

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