anti-LYZ TCR, pLXSN(TCR-L049)

The vector of anti-LYZ T cell receptor (TCR) is constructed for the engineering of T cell to target LYZ. The T cells are genetically modified through transduction with a retroviral vector expressing LYZ-specific T cell receptor. And the vector product was designed for the treatment of immunodeficiency diseases.


Details


Target
LYZ
Target Species
Chicken
Epitope
LYZ[46-61]
Format
Non-modified TCR
Targeting Diseases
Immunodeficiency diseases
Vector Name
pLXSN
Vector Length
6714-6688bp
Vector Type
retroviral vector
Antibody Host
Pig

Target


Gene Name
lysozyme (renal amyloidosis)
Official Symbol
LYZ
Gene ID
UniProt ID
Synonyms
LYZC; LYZ; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Immunodeficiency diseases
Introduction
Lysozymes, also known as muramidase or N-acetylmuramide glycanhydrolase, are glycoside hydrolases. These are enzymes (EC 3.2.1.17) that damage bacterial cell walls by catalyzing hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. Lysozyme is abundant in a number of secretions, such as tears, saliva, human milk, and mucus. It is also present in cytoplasmic granules of the macrophages and the polymorphonuclear neutrophils (PMNs). Large amounts of lysozyme can be found in egg white. C-type lysozymes are closely related to alpha-lactalbumin in sequence and structure, making them part of the same family. In humans, the lysozyme enzyme is encoded by the LYZ gene.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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