anti-MAGEA10 TCR, pMSGV1(TCR-L058)

The vector of anti-MAGEA10 T cell receptor (TCR) is constructed for the engineering of T cell to target Human MAGEA10 . The T cells are genetically modified through transduction with a retroviral vector expressing MAGEA10 -specific T cell receptor. And the vector product was designed for the treatment of Melanoma.


Details


Target
MAGEA10
Target Species
Human
Format
Non-modified TCR
HLA
HLA-A2
Targeting Diseases
Melanoma
Vector Name
pMSGV1
Vector Length
6700-8070bp
Vector Type
retroviral vector
Antibody Host
Human

Target


Gene Name
MAGE family member A10
Official Symbol
MAGEA10
Gene ID
UniProt ID
Synonyms
CT1.12; MAGE12; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Melanoma
Introduction
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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