anti-MDM2-protein TCR, pGMT7(TCR-L071)

The vector of anti-MDM2-protein T cell receptor (TCR) is constructed for the engineering of T cell to target Human MDM2-protein. The T cells are genetically modified through transduction with a retroviral vector expressing MDM2-protein-specific T cell receptor. And the vector product was designed for the treatment of cancerous diseases.


Details


Target
MDM2-protein
Target Species
Human
Epitope
STTVTKER
Format
Non-modified TCR
HLA
HLA-A2
Targeting Diseases
Cancerous diseases
Vector Name
pGMT7
Vector Length
3111bp
Vector Type
retroviral vector
Antibody Host
Mouse

Target


Gene Name
MDM2 proto-oncogene, E3 ubiquitin protein
Official Symbol
MDM2
Gene ID
UniProt ID
Synonyms
HDMX; hdm2; ACTFS; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Cancerous diseases
Introduction
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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