anti-MDM2-protein TCR, pGMT7(TCR-L071)
The vector of anti-MDM2-protein T cell receptor (TCR) is constructed for the engineering of T cell to target Human MDM2-protein. The T cells are genetically modified through transduction with a retroviral vector expressing MDM2-protein-specific T cell receptor. And the vector product was designed for the treatment of cancerous diseases.
MDM2 proto-oncogene, E3 ubiquitin protein
HDMX; hdm2; ACTFS; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Cancerous diseases
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.