anti-nef TCR, pMSGV1(TCR-L076)

The vector of anti-nef T cell receptor (TCR) is constructed for the engineering of T cell to target HIV nef . The T cells are genetically modified through transduction with a retroviral vector expressing nef -specific T cell receptor. And the vector product was designed for the treatment of AIDS.


Details


Target
nef
Target Species
HIV
Epitope
KAAVDLSHFL
Format
Non-modified TCR
HLA
HLA-C*0802
Targeting Diseases
AIDS
Vector Name
pMSGV1
Vector Length
6700-8070bp
Vector Type
retroviral vector
Antibody Host
Human

Target


Gene Name
p27
Official Symbol
nef
Gene ID
UniProt ID
Synonyms
HIV Nef; Human Immunodeficiency Viruse Nef; Human Immunodeficiency Viruse; HIV Nef protein; HIV Nef-protein; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector
; AIDS; HIV
Introduction
The HIV Nef protein is a multifunctional virulence factor that perturbs intracellular membranes and
signalling and is secreted into exosomes. While Nef-containing exosomes have a distinct proteomic
profile, no comprehensive analysis of their miRNA cargo has been carried out. Since Nef functions as a
viral suppressor of RNA interference and disturbs the distribution of RNA-induced silencing complex
proteins between cells and exosomes, we hypothesized that it might also affect the export of miRNAs
into exosomes

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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