anti-OVA TCR, pSV2-neo(TCR-L086)

The vector of anti-OVA T cell receptor (TCR) is constructed for the engineering of T cell to target OVA. The T cells are genetically modified through transduction with a retroviral vector expressing OVA-specific T cell receptor. And the vector product was designed for the treatment of Food allergy.


Details


Target
OVA
Target Species
Chicken
Epitope
SQAVHAAHAEINEAGR
Format
Non-modified TCR
Targeting Diseases
Food allergy
Vector Name
pLXSN
Vector Length
6714-6688bp
Vector Type
retroviral vector
Antibody Host
Human

Target


Gene Name
ovalbumin (SERPINB14)
Official Symbol
OVAL
Gene ID
UniProt ID
Synonyms
Tra-P1A; Trap1a; tumor rejection antigen P1A; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Spleen cancer; thymus cancer; liver cancer; lung cancer
Introduction
This peptide is amino acids 323 to 339 amidated fragment of ovalbumin (OVA), the H-2b-restricted
OVA class II epitope. This peptide is recognized by many T cells because it contains multiple T cell
epitopes. This OVA fragment contains a nested set of CD4+ T cell epitopes. OVA 323 to 339 can be
presented by I-Ad in at least three binding registers. The residues 327 to 333 are critical for peptide
binding to I-Ad

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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