anti-p53 TCR, pSFG(TCR-L089)

The vector of anti-p53 T cell receptor (TCR) is constructed for the engineering of T cell to target Human p53. The T cells are genetically modified through transduction with a retroviral vector expressing p53-specific T cell receptor. And the vector product was designed for the treatment of cancer, allergies, viral infections and autoimmune disorders.


Details


Target
p53
Target Species
Human
Epitope
LLGRNSFEV
Format
Single-chain TCR
HLA
HLA-A2.1
Targeting Diseases
Cancer, allergies, viral infections and autoimmune disorders.
Vector Name
pSFG
Vector Length
8200bp
Vector Type
retroviral vector
Antibody Host
Human

Target


Gene Name
tumor protein p53
Official Symbol
TP53
Gene ID
UniProt ID
Synonyms
PHLPI; PHLP1; Pollen allergen Phl p 1; Phl p 1; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Allergy
Introduction
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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