anti-PLP TCR, pLXSN(TCR-L095)

The vector of anti-PLP T cell receptor (TCR) is constructed for the engineering of T cell to target Mouse PLP. The T cells are genetically modified through transduction with a retroviral vector expressing PLP-specific T cell receptor. And the vector product was designed for the treatment of experimental autoimmune encephalomyelitis (EAE).


Details


Target
PLP
Target Species
Mouse
Epitope
HSLGKWLGHPDKF
Format
Non-modified TCR
HLA
HLA-A2
Targeting Diseases
Experimental autoimmune encephalomyelitis (EAE)
Vector Name
pLXSN
Vector Length
6714-6688bp
Vector Type
retroviral vector
Antibody Host
Mouse

Target


Gene Name
proteolipid protein (myelin) 1
Official Symbol
Plp1
Gene ID
UniProt ID
Synonyms
jp; Plp; msd; rsh; DM20; jimpy; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Experimental autoimmune encephalomyelitis; EAE
Introduction
This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Autoimmune Diseases

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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