anti-RAC 1 TCR, pLXSN(TCR-L103)

The vector of anti-RAC 1 T cell receptor (TCR) is constructed for the engineering of T cell to target Human RAC 1. The T cells are genetically modified through transduction with a retroviral vector expressing RAC 1-specific T cell receptor. And the vector product was designed for the treatment of Melanoma.


Details


Target
RAC 1
Target Species
Human
Epitope
FSGEYIPTV
Format
Non-modified TCR
HLA
HLA-A2
Targeting Diseases
Melanoma
Vector Name
pLXSN
Vector Length
6714-6688bp
Vector Type
retroviral vector
Antibody Host
Human

Target


Gene Name
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1
Official Symbol
RAC1
Gene ID
UniProt ID
Synonyms
MIG5; Rac-1; TC-25; p21-Rac1; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Melanoma
Introduction
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Carcinoma

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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